𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Asymmetric synthesis of camptothecin alkaloids: A nine-step synthesis of (S)-camptothecin

✍ Scribed by Daniel L. Comins; Hao Hong; Gao Jianhua


Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
221 KB
Volume
35
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Asymmetric synthesis of (S)-camptothecin
✍ Akio Ejima; Hirofumi Terasawa; Masamichi Sugimori; Hiroaki Tagawa πŸ“‚ Article πŸ“… 1989 πŸ› Elsevier Science 🌐 French βš– 119 KB
Synthetic Studies on Camptothecins. Part
✍ Li-Peng Zhang; Yong Bao; Yun-Yan Kuang; Fen-Er Chen πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 German βš– 148 KB

## Abstract A six‐step asymmetric total synthesis of (20__S__)‐camptothecin (**1**) has been accomplished in 25% overall yield starting from the known pyridone **3**. The key steps in this synthesis are the chemoselective Ni‐catalyzed hydrogenation of 3‐cyanopyridone **6** to 3‐formylpyridone **7**

Total Synthesis of (+)-Camptothecin
✍ Prof. Dr. Marco A. Ciufolini; Frank Roschangar πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 383 KB

A . F Wells. A<ru C'J I siuNogr. S c ~r A. 1986.42. 133. We are indebted to one of [7] G . M. Sheidrick. SHELX-76, Proxriiix /oi-C~.i..sro/ S i r i i m i t -c D ~, ~~~I -I I ~~I ~~I I ; ~J I ? . Condensation of phosphonate 4, Y = Z = H, with aldehyde 5 (vide infra) afforded enone 7, [ X I : ' = -56.

A total synthesis of (Β±)-camptothecin
✍ M. Shamma; D.A. Smithers; V. St. Georoiev πŸ“‚ Article πŸ“… 1973 πŸ› Elsevier Science 🌐 French βš– 491 KB