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Total Synthesis of (+)-Camptothecin

✍ Scribed by Prof. Dr. Marco A. Ciufolini; Frank Roschangar

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
383 KB
Volume
35
Category
Article
ISSN
0044-8249

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✦ Synopsis

A . F Wells. A<ru C'J I siuNogr. S c ~r A. 1986.42. 133. We are indebted to one of [7] G . M. Sheidrick. SHELX-76, Proxriiix /oi-C~.i..sro/ S i r i i m i t -c D ~, ~~~I -I I ~~I ~~I I ; ~J I ? . Condensation of phosphonate 4, Y = Z = H, with aldehyde 5 (vide infra) afforded enone 7, [ X I : ' = -56.1 (c = 4.720 in CHCI,), in 80%) yield (Scheme 2). For reasons that are not yet the referees who drew our attention to this reference.

πŸ“œ SIMILAR VOLUMES

Synthetic Studies on Camptothecins. Part
Synthetic Studies on Camptothecins. Part 1 : An Improved Asymmetric Total Synthesis of (20S)-Camptothecin
✍ Li-Peng Zhang; Yong Bao; Yun-Yan Kuang; Fen-Er Chen πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 German βš– 148 KB

## Abstract A six‐step asymmetric total synthesis of (20__S__)‐camptothecin (**1**) has been accomplished in 25% overall yield starting from the known pyridone **3**. The key steps in this synthesis are the chemoselective Ni‐catalyzed hydrogenation of 3‐cyanopyridone **6** to 3‐formylpyridone **7**