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Total Synthesis of (+)-Camptothecin.

✍ Scribed by Brian S. J. Blagg; Dale L. Boger

Publisher
John Wiley and Sons
Year
2010
Weight
23 KB
Volume
33
Category
Article
ISSN
0931-7597

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πŸ“œ SIMILAR VOLUMES

Total Synthesis of (+)-Camptothecin
Total Synthesis of (+)-Camptothecin
✍ Prof. Dr. Marco A. Ciufolini; Frank Roschangar πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 383 KB

A . F Wells. A<ru C'J I siuNogr. S c ~r A. 1986.42. 133. We are indebted to one of [7] G . M. Sheidrick. SHELX-76, Proxriiix /oi-C~.i..sro/ S i r i i m i t -c D ~, ~~~I -I I ~~I ~~I I ; ~J I ? . Condensation of phosphonate 4, Y = Z = H, with aldehyde 5 (vide infra) afforded enone 7, [ X I : ' = -56.

Synthetic Studies on Camptothecins. Part
Synthetic Studies on Camptothecins. Part 1 : An Improved Asymmetric Total Synthesis of (20S)-Camptothecin
✍ Li-Peng Zhang; Yong Bao; Yun-Yan Kuang; Fen-Er Chen πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 German βš– 148 KB

## Abstract A six‐step asymmetric total synthesis of (20__S__)‐camptothecin (**1**) has been accomplished in 25% overall yield starting from the known pyridone **3**. The key steps in this synthesis are the chemoselective Ni‐catalyzed hydrogenation of 3‐cyanopyridone **6** to 3‐formylpyridone **7**