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Asymmetric synthesis of (S)-camptothecin

✍ Scribed by Akio Ejima; Hirofumi Terasawa; Masamichi Sugimori; Hiroaki Tagawa

Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
119 KB
Volume
30
Category
Article
ISSN
0040-4039

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πŸ“œ SIMILAR VOLUMES

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## Abstract A six‐step asymmetric total synthesis of (20__S__)‐camptothecin (**1**) has been accomplished in 25% overall yield starting from the known pyridone **3**. The key steps in this synthesis are the chemoselective Ni‐catalyzed hydrogenation of 3‐cyanopyridone **6** to 3‐formylpyridone **7**

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