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Enantioselective synthesis of 20(S)-camptothecin using sharpless catalytic asymmetric dihydroxylation

✍ Scribed by Sang-sup Jew; Kwang-dae Ok; Hee-jin Kim; Myoung Goo Kim; Jong Min Kim; Jeong Mi Hah; Youn-sang Cho

Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 218 KB
Volume: 6
Category: Article
ISSN: 0957-4166
DOI: 10.1016/0957-4166(95)00154-h

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## Abstract A six‐step asymmetric total synthesis of (20__S__)‐camptothecin (**1**) has been accomplished in 25% overall yield starting from the known pyridone **3**. The key steps in this synthesis are the chemoselective Ni‐catalyzed hydrogenation of 3‐cyanopyridone **6** to 3‐formylpyridone **7**