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Novel syntheses of camptothecin alkaloids, part 2. concise synthesis of (S)-camptothecins

โœ Scribed by Joseph M.D Fortunak; John Kitteringham; Antonietta R Mastrocola; Mark Mellinger; Nicolas J Sisti; Jeffery L Wood; Zhi-Ping Zhuang


Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
233 KB
Volume
37
Category
Article
ISSN
0040-4039

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๐Ÿ“œ SIMILAR VOLUMES


Synthetic Studies on Camptothecins. Part
โœ Li-Peng Zhang; Yong Bao; Yun-Yan Kuang; Fen-Er Chen ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ German โš– 148 KB

## Abstract A sixโ€step asymmetric total synthesis of (20__S__)โ€camptothecin (**1**) has been accomplished in 25% overall yield starting from the known pyridone **3**. The key steps in this synthesis are the chemoselective Niโ€catalyzed hydrogenation of 3โ€cyanopyridone **6** to 3โ€formylpyridone **7**

ChemInform Abstract: Novel C-Ring Analog
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## 2. Synthesis and in vitro Cytotoxicity of 5-C-Substituted 20(S)-Camptothecin Analogues. -A series of several 5-substituted camptothecin analogues [cf. (II), (IV), (VI)] are synthesized from the natural alkaloid (I) and evaluated for their in vitro anticancer activity. Some of these analogues, e

Synthetic Studies on Camptothecins. Part
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## Abstract A concise and efficient asymmetric process for the total synthesis of (20__S__)โ€7โ€ethylโ€10โ€hydroxycamptothecin (=SNโ€38; **1f**), an active metabolic form of the prodrug irinotecan, is described. This approach features the enantioselective cyanosilylation of indolizinone **4** into the c