Novel syntheses of camptothecin alkaloids, part 2. concise synthesis of (S)-camptothecins
โ Scribed by Joseph M.D Fortunak; John Kitteringham; Antonietta R Mastrocola; Mark Mellinger; Nicolas J Sisti; Jeffery L Wood; Zhi-Ping Zhuang
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 233 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract A sixโstep asymmetric total synthesis of (20__S__)โcamptothecin (**1**) has been accomplished in 25% overall yield starting from the known pyridone **3**. The key steps in this synthesis are the chemoselective Niโcatalyzed hydrogenation of 3โcyanopyridone **6** to 3โformylpyridone **7**
## 2. Synthesis and in vitro Cytotoxicity of 5-C-Substituted 20(S)-Camptothecin Analogues. -A series of several 5-substituted camptothecin analogues [cf. (II), (IV), (VI)] are synthesized from the natural alkaloid (I) and evaluated for their in vitro anticancer activity. Some of these analogues, e
## Abstract A concise and efficient asymmetric process for the total synthesis of (20__S__)โ7โethylโ10โhydroxycamptothecin (=SNโ38; **1f**), an active metabolic form of the prodrug irinotecan, is described. This approach features the enantioselective cyanosilylation of indolizinone **4** into the c