Substituted 3-hydroxyquinoline-2,4(1H,3H )-diones 3 were transformed into 3-acyloxy-1,3-dihydro-2H-indol-2-ones 4 and isomeric 4-acyl-1,4-dihydro-3,1-benzoxazin-2-ones 5. The influence of the substituents and the reaction conditions on the course of the reaction was studied. In the proposed mechanis
Novel syntheses of camptothecin alkaloids, part I. Intramolecular [4+2] cycloadditions of N-arylimidates and 4H-3,1-benzoxazin-4-ones as 2-aza-1,3-dienes
✍ Scribed by Joseph M.D Fortunak; Antonietta R Mastrocola; Mark Mellinger; Nicolas J Sisti; Jeffery L Wood; Zhi-Ping Zhuang
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 217 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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## Abstract 1‐Mono‐ and previously unknown 1,2‐disubstituted 1,2‐dihydro‐3,1‐benzoxazin‐4‐ones 7 and 9, potential prodrugs of flufenamic acid (6) and mefenamic acid (8), and 4__H__‐1,2‐dihydro‐pyrido‐[2,3‐__d__]‐[1,3]‐oxazin‐4‐ones 11, potential prodrugs of niflumic acid (10), were prepared; the st
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v