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Syntheses of Vinca Alkaloids and Related Compounds. Part 104. A Concise Synthesis of (-)-Vincapusine (I).

โœ Scribed by Istvan Moldvai; Tamas Gati; Csaba Jr. Szantay; Csaba Szantay


Publisher
John Wiley and Sons
Year
2006
Weight
9 KB
Volume
37
Category
Article
ISSN
0931-7597

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The bisindole alkaloids vinblastine, vincristine, and N-formyl-leurosine were nitrated and subsequently converted to amino derivatives. In the case of compounds 5e and 5b cytotoxic activity has been found for non-small cell lung cancer and breast cancer in the concentration range tested (10(-5)-10(-