Synthesis of vinca alkaloids and related compounds, Part XCVI [1] Nitration study of vinblastine-type bisindole alkaloids

✍ Scribed by Lajos Szabó; Hedvig Bölcskei; Baitz-Gács Eszter; Marianna Mák; Csaba Szántay

• Publisher: John Wiley and Sons
• Year: 2001
• Tongue: English
• Weight: 86 KB
• Volume: 334
• Category: Article
• ISSN: 0365-6233
• DOI: 10.1002/1521-4184(200112)334:12<399::aid-ardp399>3.0.co;2-1

✦ Synopsis

The bisindole alkaloids vinblastine, vincristine, and N-formyl-leurosine were nitrated and subsequently converted to amino derivatives. In the case of compounds 5e and 5b cytotoxic activity has been found for non-small cell lung cancer and breast cancer in the concentration range tested (10(-5)-10(-9) M). 5b also showed potency in the screen for colon cancer and leukemia.