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ChemInform Abstract: Synthesis of Vinca Alkaloids and Related Compounds. Part 82. An Unexpected Neber-Type Rearrangement.

✍ Scribed by I. MOLDVAI; C. JUN. SZANTAY; C. SZANTAY


Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
28
Category
Article
ISSN
0931-7597

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The bisindole alkaloids vinblastine, vincristine, and N-formyl-leurosine were nitrated and subsequently converted to amino derivatives. In the case of compounds 5e and 5b cytotoxic activity has been found for non-small cell lung cancer and breast cancer in the concentration range tested (10(-5)-10(-