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ChemInform Abstract: Synthesis of Vinca Alkaloids and Related Compounds. Part 96. Nitration Study of Vinblastine-Type Bisindole Alkaloids.

✍ Scribed by Lajos Szabo; Hedvig Boelcskei; Baitz-Gacs Eszter; Marianna Mak; Csaba Szantay

Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
33
Category
Article
ISSN
0931-7597

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Synthesis of vinca alkaloids and related
Synthesis of vinca alkaloids and related compounds, Part XCVI [1] Nitration study of vinblastine-type bisindole alkaloids
✍ Lajos SzabΓ³; Hedvig BΓΆlcskei; Baitz-GΓ‘cs Eszter; Marianna MΓ‘k; Csaba SzΓ‘ntay πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 86 KB πŸ‘ 2 views

The bisindole alkaloids vinblastine, vincristine, and N-formyl-leurosine were nitrated and subsequently converted to amino derivatives. In the case of compounds 5e and 5b cytotoxic activity has been found for non-small cell lung cancer and breast cancer in the concentration range tested (10(-5)-10(-