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Synthesis of Vinca Alkaloids and Related Compounds, XLIV1): Synthesis of Trifluoro-apovincaminic Acid Ester

✍ Scribed by Märia Incze; Ferenc Sóti; Zsuzsanna Kardos-Balogh; MÁRia Kajtár-Peredy; Csaba Szántay


Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
262 KB
Volume
323
Category
Article
ISSN
0365-6233

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Synthesis of vinca alkaloids and related
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The bisindole alkaloids vinblastine, vincristine, and N-formyl-leurosine were nitrated and subsequently converted to amino derivatives. In the case of compounds 5e and 5b cytotoxic activity has been found for non-small cell lung cancer and breast cancer in the concentration range tested (10(-5)-10(-