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Synthesis of Vinca Alkaloids and Related Compounds, LXI: Synthesis of Ethyl (±)-17α,21-Epoxy-apovincaminate

✍ Scribed by Ferenc Sóti; Mária Incze; Zsuzsanna Kardos-Balogh; Mária Kajtár-Peredy; Csaba Szántay

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
194 KB
Volume
326
Category
Article
ISSN
0365-6233

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Synthesis of vinca alkaloids and related
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✍ Lajos Szabó; Hedvig Bölcskei; Baitz-Gács Eszter; Marianna Mák; Csaba Szántay 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 86 KB 👁 2 views

The bisindole alkaloids vinblastine, vincristine, and N-formyl-leurosine were nitrated and subsequently converted to amino derivatives. In the case of compounds 5e and 5b cytotoxic activity has been found for non-small cell lung cancer and breast cancer in the concentration range tested (10(-5)-10(-