A . F Wells. A<ru C'J I siuNogr. S c ~r A. 1986.42. 133. We are indebted to one of [7] G . M. Sheidrick. SHELX-76, Proxriiix /oi-C~.i..sro/ S i r i i m i t -c D ~, ~~~I -I I ~~I ~~I I ; ~J I ? . Condensation of phosphonate 4, Y = Z = H, with aldehyde 5 (vide infra) afforded enone 7, [ X I : ' = -56.
A total synthesis of (±)-camptothecin
✍ Scribed by M. Shamma; D.A. Smithers; V. St. Georoiev
- Publisher
- Elsevier Science
- Year
- 1973
- Tongue
- French
- Weight
- 491 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0040-4020
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Introduction.. Camptothecin (CPT, 1) 2 and related compounds 3 have recently returned to the forefront of experimental cancer treatment. 4 Good evidence regarding their biomolecular target and mode of action has been produced. 5 Furthermore, previously unrecognized antiviral properties 6 and modulat
## Abstract A concise and efficient asymmetric process for the total synthesis of (20__S__)‐7‐ethyl‐10‐hydroxycamptothecin (=SN‐38; **1f**), an active metabolic form of the prodrug irinotecan, is described. This approach features the enantioselective cyanosilylation of indolizinone **4** into the c