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Anti-endothelial properties of 1,25-dihydroxy-3-epi-vitamin D3, a natural metabolite of calcitriol

✍ Scribed by Paul Furigay; Narasimha Swamy


Book ID
116697312
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
195 KB
Volume
89-90
Category
Article
ISSN
0960-0760

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1␣,25(OH) 2 D 3 is an important negative regulator of parathyroid hormone (PTH) gene transcription. In parathyroid cells, as in other target tissues, 1␣,25(OH) 2 D 3 is degraded by side chain oxidation by the inducible 24-hydroxylase. We have previously shown that one metabolite of this pathway, 1␣,