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An efficient synthesis of 1α,25-dihydroxy-20-epi-vitamin D3

✍ Scribed by Fraga, R.; López-Pérez, B.; Sokolowska, K.; Guini, A.; Regueira, T.; Díaz, S.; Mouriño, A.; Maestro, M.A.


Book ID
122813680
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
314 KB
Volume
136
Category
Article
ISSN
0960-0760

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An efficient synthesis of the title compound is reported based on C-l functionalization of the triazoline Diels-Alder adduct of 25-OH previtamin D3 (2). lu,25-Dihydroxy vitamin D3 (la) is considered as the most important and active natural metabolite of vitamin D 1 3 -Recently we have described a no