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1α,25-Dihydroxy-3-epi-vitamin D3: In vivo metabolite of 1α,25-dihydroxyvitamin D3 in rats

✍ Scribed by H Sekimoto; M.-L Siu-Caldera; A Weiskopf; P Vouros; K.R Muralidharan; W.H Okamura; M.R Uskokovic; G.S Reddy

Book ID
117110694
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
170 KB
Volume
448
Category
Article
ISSN
0014-5793

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✍ A.J. Brown; C. Ritter; E. Slatopolsky; K.R. Muralidharan; W.H. Okamura; G.S. Red 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 130 KB 👁 1 views

1␣,25(OH) 2 D 3 is an important negative regulator of parathyroid hormone (PTH) gene transcription. In parathyroid cells, as in other target tissues, 1␣,25(OH) 2 D 3 is degraded by side chain oxidation by the inducible 24-hydroxylase. We have previously shown that one metabolite of this pathway, 1␣,