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1α,25-Dihydroxy-3-epi-vitamin D3, a natural metabolite of 1α,25-dihydroxy vitamin D3: production and biological activity studies in pulmonary alveolar type II cells

✍ Scribed by Virender K Rehan; John S Torday; Sara Peleg; Lynn Gennaro; Paul Vouros; James Padbury; D Sunita Rao; G Satyanarayana Reddy

Book ID
117735368
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
391 KB
Volume
76
Category
Article
ISSN
1096-7192

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1␣,25(OH) 2 D 3 is an important negative regulator of parathyroid hormone (PTH) gene transcription. In parathyroid cells, as in other target tissues, 1␣,25(OH) 2 D 3 is degraded by side chain oxidation by the inducible 24-hydroxylase. We have previously shown that one metabolite of this pathway, 1␣,