The biological activities of pure crystalline 1α-hydroxy vitamin D3 and 1α,25-dihydroxy vitamin D3
✍ Scribed by Pechet, Maurice M.; Hesse, Robert H.
- Book ID
- 123041587
- Publisher
- Elsevier Science
- Year
- 1974
- Tongue
- English
- Weight
- 135 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0303-7207
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An efficient synthesis of the title compound is reported based on C-l functionalization of the triazoline Diels-Alder adduct of 25-OH previtamin D3 (2). lu,25-Dihydroxy vitamin D3 (la) is considered as the most important and active natural metabolite of vitamin D 1 3 -Recently we have described a no
1a,25-dihydroxy vitamin D3 has a major role in the regulation of the bone metabolism as it promotes the expression of key bone-related proteins in osteoblastic cells. In recent years it has become increasingly evident that in addition to its well-established genomic actions, 1a,25-dihydroxy vitamin