A fluorinated vitamin D3 analog with biopotency greater than 1α,25-dihydroxy vitamin D3
✍ Scribed by R.A. Corradino; H.F. DeLuca; Y. Tanaka; N. Ikekawa; Y. Kobayashi
- Book ID
- 118315027
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- English
- Weight
- 184 KB
- Volume
- 96
- Category
- Article
- ISSN
- 0006-291X
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l~,25-Dihydroxy-19-nor-vitamin D 3 has been synthesized via oxidative degradation of the l~-hydroxycylcovitamin intermediate. Preliminary studies indicate that the new analog induces the differentiation of human leukemia HL-60 cells, with little or no calcemic activity. The hormone, l~,25-dihydrox