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Analysis of RAD51C germline mutations in high-risk breast and ovarian cancer families and ovarian cancer patients

✍ Scribed by ER Thompson; SE Boyle; J Johnson; GL Ryland; S Sawyer; DY Choong; kConFab; G Chenevix-Trench; AH Trainer; GJ Lindeman; G Mitchell; PA James; IG Campbell


Book ID
115027844
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
80 KB
Volume
10
Category
Article
ISSN
1897-4287

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Analysis of RAD51C germline mutations in
✍ Ella R. Thompson; Samantha E. Boyle; Julie Johnson; Georgina L. Ryland; Sarah Sa πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 180 KB

There is strong evidence that overtly inactivating mutations in RAD51C predispose to hereditary breast and ovarian cancer but the prevalence of such mutations, and whether they are associated with a particular clinical phenotype, remains unclear. Resolving these questions has important implications