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RAD51C germline mutations in breast and ovarian cancer patients

✍ Scribed by Mohammad R Akbari, Patricia Tonin, William D Foulkes…

Book ID
120699032
Publisher
BioMed Central
Year
2010
Tongue
English
Weight
115 KB
Volume
12
Category
Article
ISSN
1465-5411

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✍ Ella R. Thompson; Samantha E. Boyle; Julie Johnson; Georgina L. Ryland; Sarah Sa 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 180 KB

There is strong evidence that overtly inactivating mutations in RAD51C predispose to hereditary breast and ovarian cancer but the prevalence of such mutations, and whether they are associated with a particular clinical phenotype, remains unclear. Resolving these questions has important implications