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Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene

✍ Scribed by Schaal, Heiner; Meindl, Alfons; Hellebrand, Heide; Wiek, Constanze; Erven, Verena; Wappenschmidt, Barbara; Niederacher, Dieter; Freund, Marcel; Lichtner, Peter; Hartmann, Linda


Book ID
109914597
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
646 KB
Volume
42
Category
Article
ISSN
1061-4036

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Analysis of RAD51C germline mutations in
✍ Ella R. Thompson; Samantha E. Boyle; Julie Johnson; Georgina L. Ryland; Sarah Sa πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 180 KB

There is strong evidence that overtly inactivating mutations in RAD51C predispose to hereditary breast and ovarian cancer but the prevalence of such mutations, and whether they are associated with a particular clinical phenotype, remains unclear. Resolving these questions has important implications