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Adenosine-Derived Non-Phosphate Antagonists for P2Y1 Purinoceptors

✍ Scribed by Katrin Sak; Asko Uri; Erki Enkvist; Gerda Raidaru; Juhan Subbi; Merike Kelve; Jaak Järv


Book ID
115585861
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
91 KB
Volume
272
Category
Article
ISSN
0006-291X

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Benzofuran-substituted urea analogs have been identified as novel P2Y(1) receptor antagonists. Structure-activity relationship studies around the urea and the benzofuran moieties resulted in compounds having improved potency. Several analogs were shown to inhibit ADP-mediated platelet activation.