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Adenosine 5‘- O -(1-Boranotriphosphate) Derivatives as Novel P2Y 1 Receptor Agonists

✍ Scribed by Nahum, Victoria; Zündorf, Gregor; Lévesque, Sébastien A.; Beaudoin, Adrien R.; Reiser, Georg; Fischer, Bilha


Book ID
126438974
Publisher
American Chemical Society
Year
2002
Tongue
English
Weight
247 KB
Volume
45
Category
Article
ISSN
0022-2623

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Benzofuran-substituted urea analogs have been identified as novel P2Y(1) receptor antagonists. Structure-activity relationship studies around the urea and the benzofuran moieties resulted in compounds having improved potency. Several analogs were shown to inhibit ADP-mediated platelet activation.