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Benzofuran-substituted urea derivatives as novel P2Y1 receptor antagonists

✍ Scribed by Reema K. Thalji; Nambi Aiyar; Elizabeth A. Davenport; Joseph A. Erhardt; Lorena A. Kallal; Dwight M. Morrow; Shobha Senadhi; Cynthia L. Burns-Kurtis; Joseph P. Marino Jr.

Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 249 KB
Volume: 20
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2010.05.072

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✦ Synopsis

Benzofuran-substituted urea analogs have been identified as novel P2Y(1) receptor antagonists. Structure-activity relationship studies around the urea and the benzofuran moieties resulted in compounds having improved potency. Several analogs were shown to inhibit ADP-mediated platelet activation.

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