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Novel Phthalimide Derivatives, Designed as Leukotriene D4 Receptor Antagonists.

✍ Scribed by Lidia M. Lima; Fernanda C. F. de Brito; Simone D. de Souza; Ana L. P. Miranda; Carlos R. Rodrigues; Carlos A. M. Fraga; Eliezer J. Barreiro

Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
33
Category
Article
ISSN
0931-7597

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Benzofuran-substituted urea analogs have been identified as novel P2Y(1) receptor antagonists. Structure-activity relationship studies around the urea and the benzofuran moieties resulted in compounds having improved potency. Several analogs were shown to inhibit ADP-mediated platelet activation.