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Phosphate-Substituted ATP Analogs Are Antagonists at Human P2Y1 Purinoceptors

✍ Scribed by Katrin Sak; Gerda Raidaru; Tania E. Webb; Jaak Järv

Book ID
115568379
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
48 KB
Volume
381
Category
Article
ISSN
0003-9861

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Adenosine 5'-diphosphate (ADP) induces human platelet aggregation and inhibits stimulated adenylate cyclase by an action at P,,-purinoceptors. Both of these effects of ADP are inhibited competitively by ATP. Structure-activity relationships for phosphate-modified analogs of ADP and adenosine 5'-tri