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Synthesis of pyridoxal phosphate derivatives with antagonist activity at the P2Y13 receptor

✍ Scribed by Yong-Chul Kim; Jung-Sun Lee; Katrin Sak; Frederic Marteau; Liaman Mamedova; Jean-Marie Boeynaems; Kenneth A. Jacobson

Book ID
113487597
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
206 KB
Volume
70
Category
Article
ISSN
0006-2952

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Novel analogs of the P2 receptor antagonist pyridoxal-5′-phosphate-6-phenylazo-2′,4′disulfonate (PPADS) were synthesized. Modifications were made through functional group substitution on the sulfophenyl ring and at the phosphate moiety through the inclusion of phosphonates, demonstrating that a phos