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The novel pyridoxal-5′-phosphate derivative PPNDS potently antagonizes activation of P2X1 receptors

✍ Scribed by Günter Lambrecht; Jürgen Rettinger; Hans G Bäumert; Sittah Czeche; Susanne Damer; Matthias Ganso; Caren Hildebrandt; Beate Niebel; Gerhard Spatz-Kümbel; Günther Schmalzing; Ernst Mutschler


Book ID
114017755
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
54 KB
Volume
387
Category
Article
ISSN
0014-2999

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Novel analogs of the P2 receptor antagonist pyridoxal-5′-phosphate-6-phenylazo-2′,4′disulfonate (PPADS) were synthesized. Modifications were made through functional group substitution on the sulfophenyl ring and at the phosphate moiety through the inclusion of phosphonates, demonstrating that a phos