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Synthesis and Structure−Activity Relationships of Suramin-Derived P2Y 11 Receptor Antagonists with Nanomolar Potency

✍ Scribed by Ullmann, Heiko; Meis, Sabine; Hongwiset, Darunee; Marzian, Claudia; Wiese, Michael; Nickel, Peter; Communi, Didier; Boeynaems, Jean-Marie; Wolf, Christian; Hausmann, Ralf; Schmalzing, Günther; Kassack, Matthias U.


Book ID
121222823
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
227 KB
Volume
48
Category
Article
ISSN
0022-2623

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Novel analogs of the P2 receptor antagonist pyridoxal-5′-phosphate-6-phenylazo-2′,4′disulfonate (PPADS) were synthesized. Modifications were made through functional group substitution on the sulfophenyl ring and at the phosphate moiety through the inclusion of phosphonates, demonstrating that a phos