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Synthesis and structure–activity relationships of carboxylic acid derivatives of pyridoxal as P2X receptor antagonists

✍ Scribed by Jung, Kwan-Young; Cho, Joong-Heui; Lee, Jung Sun; Kim, Hyo Jun; Kim, Yong-Chul


Book ID
122795566
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
626 KB
Volume
21
Category
Article
ISSN
0968-0896

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Synthesis and structure-activity relatio
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Novel analogs of the P2 receptor antagonist pyridoxal-5′-phosphate-6-phenylazo-2′,4′disulfonate (PPADS) were synthesized. Modifications were made through functional group substitution on the sulfophenyl ring and at the phosphate moiety through the inclusion of phosphonates, demonstrating that a phos