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Identification of L-Tryptophan Derivatives with Potent and Selective Antagonist Activity at the NK1 Receptor

✍ Scribed by MacLeod, Angus M.; Merchant, Kevin J.; Brookfield, Frederick; Kelleher, Fintan; Stevenson, Graeme; Owens, Andrew P.; Swain, Christopher J.; Cascieri, Margaret A.; Sadowski, Sharon

Book ID: 127227051
Publisher: American Chemical Society
Year: 1994
Tongue: English
Weight: 824 KB
Volume: 37
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm00035a006

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## Abstract The airways' pharmacology of DNK333 ((1R,3R,2E)‐N‐[3,4‐dichlorobenzyl)]‐4‐[(hexahydro‐2‐oxo‐1H‐azepin‐3‐yl)amino]‐N‐methyl‐3,5bis(trifluoromethyl) benzamide), a potent and selective dual NK~1~/NK~2~ neurokinin receptor antagonist is described in the present paper. DNK333 bound with high