## Abstract We present ten cases of posterior uveal melanoma which were karyotyped after shortβterm culture. One tumour had a normal chromosome complement. The remaining nine tumours were cytogenetically abnormal, with chromosomes 3, 6, 8, 11, and 13 most frequently involved. Abnormalities of chrom
Abnormalities of chromosomes 3, 6 and 8 in posterior uveal melanoma
β Scribed by K. Sisley; I.G. Rennie; D.W. Cottam; A.M. Potter; R.C. Rees
- Book ID
- 119105742
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 75 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0165-4608
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Posterior uveal melanomas have nonrandom alterations affecting chromosomes 3, 6, and 8. Loss of chromosome 3 in uveal melanoma has been shown to act as a predictor of disease-free and overall survival. To confirm the significance of chromosome 3 loss and to extend the observations to include those o
## Abstract Six posterior uveal melanomas were karyotyped after shortβterm culture. One had a normal chromosome complement; the remaining five had limited chromosome changes. Involvement of chromosomes 1 and 6 was noted in two and four cases, respectively, and three ciliary body tumours demonstrate
lnstitut fur Humangenetik (B.H.), lnnere Klinik und Poliklinik (Tumorfonchung) (G.P., R.B.), and Zentrum fur Augenheilkunde (N.B.). Univenitatsklinikum Essen, Federal Republic of Germany Uveal melanoma is the most frequent primary intraocular tumor. The etiology is unknown. Using neutral DNA polymo