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Abnormalities of chromosomes 3, 6 and 8 in posterior uveal melanoma

✍ Scribed by K. Sisley; I.G. Rennie; D.W. Cottam; A.M. Potter; R.C. Rees


Book ID
119105742
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
75 KB
Volume
63
Category
Article
ISSN
0165-4608

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Non-random abnormalities of chromosomes
✍ Karen Sisley; David W. Cottam; Ian G. Rennie; M. Andrew Parsons; Anthony M. Pott πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 342 KB

## Abstract We present ten cases of posterior uveal melanoma which were karyotyped after short‐term culture. One tumour had a normal chromosome complement. The remaining nine tumours were cytogenetically abnormal, with chromosomes 3, 6, 8, 11, and 13 most frequently involved. Abnormalities of chrom

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Posterior uveal melanomas have nonrandom alterations affecting chromosomes 3, 6, and 8. Loss of chromosome 3 in uveal melanoma has been shown to act as a predictor of disease-free and overall survival. To confirm the significance of chromosome 3 loss and to extend the observations to include those o

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lnstitut fur Humangenetik (B.H.), lnnere Klinik und Poliklinik (Tumorfonchung) (G.P., R.B.), and Zentrum fur Augenheilkunde (N.B.). Univenitatsklinikum Essen, Federal Republic of Germany Uveal melanoma is the most frequent primary intraocular tumor. The etiology is unknown. Using neutral DNA polymo