✦ LIBER ✦

Non-random abnormalities of chromosomes 3, 6, and 8 associated with posterior uveal melanoma

✍ Scribed by Karen Sisley; David W. Cottam; Ian G. Rennie; M. Andrew Parsons; Anthony M. Potter; Christopher W. Potter; Robert C. Rees

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 342 KB
Volume: 5
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870050304

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

We present ten cases of posterior uveal melanoma which were karyotyped after short‐term culture. One tumour had a normal chromosome complement. The remaining nine tumours were cytogenetically abnormal, with chromosomes 3, 6, 8, 11, and 13 most frequently involved. Abnormalities of chromosome 13 were seen in two cases, chromosome 11 in three cases, and chromosomes 3, 6, and 8 in five cases. Four tumours, all derived from the ciliary body, demonstrated monosomy 3 and i(8q), confirming the involvement of these aberrations with a subgroup of uveal melanomas arising from the ciliary body.

📜 SIMILAR VOLUMES

Abnormalities of chromosomes 3 and 8 in

Abnormalities of chromosomes 3 and 8 in posterior uveal melanoma correlate with prognosis

✍ Karen Sisley; Ian G. Rennie; M. Andrew Parsons; Rhona Jacques; David W. Hammond; 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 125 KB 👁 2 views

Posterior uveal melanomas have nonrandom alterations affecting chromosomes 3, 6, and 8. Loss of chromosome 3 in uveal melanoma has been shown to act as a predictor of disease-free and overall survival. To confirm the significance of chromosome 3 loss and to extend the observations to include those o

Cytogenetic findings in six posterior uv

Cytogenetic findings in six posterior uveal melanomas: Involvement of chromosomes 3, 6, and 8

✍ Dr. Karen Sisley; Ian G. Rennie; David W. Cottam; Anthony M. Potter; Christopher 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 391 KB

## Abstract Six posterior uveal melanomas were karyotyped after short‐term culture. One had a normal chromosome complement; the remaining five had limited chromosome changes. Involvement of chromosomes 1 and 6 was noted in two and four cases, respectively, and three ciliary body tumours demonstrate