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Cytogenetic findings in six posterior uveal melanomas: Involvement of chromosomes 3, 6, and 8

✍ Scribed by Dr. Karen Sisley; Ian G. Rennie; David W. Cottam; Anthony M. Potter; Christopher W. Potter; Robert C. Rees

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
391 KB
Volume
2
Category
Article
ISSN
1045-2257

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✦ Synopsis

Abstract

Six posterior uveal melanomas were karyotyped after short‐term culture. One had a normal chromosome complement; the remaining five had limited chromosome changes. Involvement of chromosomes 1 and 6 was noted in two and four cases, respectively, and three ciliary body tumours demonstrated both monosomy 3 and i(8q).

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lnstitut fur Humangenetik (B.H.), lnnere Klinik und Poliklinik (Tumorfonchung) (G.P., R.B.), and Zentrum fur Augenheilkunde (N.B.). Univenitatsklinikum Essen, Federal Republic of Germany Uveal melanoma is the most frequent primary intraocular tumor. The etiology is unknown. Using neutral DNA polymo