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Loss of chromosome 3 alleles and multiplication of chromosome 8 alleles in uveal melanoma

✍ Scribed by Barnhard Horsthemke; Gabriele Prescher; Reinhard Becher; Norbert Bornfeld

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 486 KB
Volume: 4
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870040305

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✦ Synopsis

lnstitut fur Humangenetik (B.H.), lnnere Klinik und Poliklinik (Tumorfonchung) (G.P., R.B.), and Zentrum fur Augenheilkunde (N.B.).

Univenitatsklinikum Essen, Federal Republic of Germany Uveal melanoma is the most frequent primary intraocular tumor. The etiology is unknown. Using neutral DNA polymorphisms on chromosomes 2, 3, and 8, we have detected loss of chromosome 3 alleles in 8 of 13 tumors and multiplication of chromosome 8 alleles in 6 of I I tumors. No anomalies at a locus on chromosome 2 were found in I0 of I0 tumors. These results confirm and extend previous cytogenetic findings and suggest that a tumor suppressor gene on chromosome 3 and an oncogene on chromosome 8 may be involved in the formation o r progression of this tumor. Genes Chrom Cancer 4 2 I7-22 I (1 992) @ 1992 Wiley-Liss, Inc.

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