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Frequent allelic loss and homozygous deletion in chromosome band 8p23 in oral cancer

✍ Scribed by Chandramohan S. Ishwad; Michele Shuster; Ulrike Bockmühl; Nalin Thakker; Punit Shah; Carmel Toomes; Michael Dixon; Robert E. Ferrell; Susanne M. Gollin

Publisher
John Wiley and Sons
Year
1999
Tongue
French
Weight
304 KB
Volume
80
Category
Article
ISSN
0020-7136

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✦ Synopsis

Frequent loss of heterozygosity on chromosome 8p in a variety of human malignancies, including head and neck cancers, has suggested the presence of a tumor suppressor gene (or genes) associated with the pathogenesis of these cancers. To test the role of genetic alterations at 8p23 in oral carcinogenesis, we studied 51 squamous cell carcinomas of the head and neck and 29 oral squamous cell carcinoma cell lines for allelic loss using 7 microsatellite markers spanning approximately 5 cM of chromosome band 8p23. Twentythree of 51 tumors (45%) and 23 of 29 cell lines (79%) showed allelic loss at 1 or more loci. Three cell lines showed homozygous deletion of loci within a 3 cM region defined by the markers D8S1781 and D8S262. Our results suggest that a tumor suppressor gene (or genes) is located in 8p23 and is associated with the development and/or progression of oral carcinomas.

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