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Cytogenetic findings on six posterior uveal melanomas. Involvement of chromosomes. 3, 6 and 8.

✍ Scribed by K. Sisley; I.G. Rennie; D. Cottom; A.M. Potter; C.W. Potter; R.C. Rees


Book ID
119105146
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
52 KB
Volume
52
Category
Article
ISSN
0165-4608

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Cytogenetic findings in six posterior uv
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## Abstract Six posterior uveal melanomas were karyotyped after short‐term culture. One had a normal chromosome complement; the remaining five had limited chromosome changes. Involvement of chromosomes 1 and 6 was noted in two and four cases, respectively, and three ciliary body tumours demonstrate

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Posterior uveal melanomas have nonrandom alterations affecting chromosomes 3, 6, and 8. Loss of chromosome 3 in uveal melanoma has been shown to act as a predictor of disease-free and overall survival. To confirm the significance of chromosome 3 loss and to extend the observations to include those o