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A New Synthesis of Lysophosphatidylcholines and Related Derivatives. Use of p -Toluenesulfonate for Hydroxyl Group Protection

✍ Scribed by Rosseto, Renato; Bibak, Niloufar; DeOcampo, Rosemarie; Shah, Trishul; Gabrielian, Ara; Hajdu, Joseph


Book ID
126161757
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
141 KB
Volume
72
Category
Article
ISSN
0022-3263

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A new approach to the synthesis of lysop
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A new stereospecific synthesis of lysophosphatidylcholines is reported. The sequence relies on orthogonal protection of hydroxyl groups derived from glyceric acid, using fluorenylmethylcarbonate versus tetrahydropyranyl ether functions, that allow regiospecific introduction of substituents to obtain