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A new approach to the synthesis of lysophosphatidylcholines and related derivatives

✍ Scribed by Niloufar Bibak; Joseph Hajdu

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 120 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)01419-9

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✦ Synopsis

A new stereospecific synthesis of lysophosphatidylcholines is reported. The sequence relies on orthogonal protection of hydroxyl groups derived from glyceric acid, using fluorenylmethylcarbonate versus tetrahydropyranyl ether functions, that allow regiospecific introduction of substituents to obtain the target phospholipid compound.

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