✦ LIBER ✦

A new approach to the synthesis of β-fluoropyrrole derivatives

✍ Scribed by Zai-Ming Qiu; Donald J. Burton

Publisher: Elsevier Science
Year: 1994
Tongue: French
Weight: 310 KB
Volume: 35
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)73343-0

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✦ Synopsis

j%Flaoropyrrole derivatives are qnthesized in high yields by the reaction of a,a-difluoro-+odo-y(electron-witMrawlng-group)-slrbsrirvred ketones and ammo&~ hy&ozdde a~ mom tempcrorurc; providing a new, simple. and q@Icient waethod for the synthesis Qj3-jiuorinatedpyrrole tings.

A possible wuchatdsw~ is proposed.

Pyrrole and its derivatives are one of the most important heterocyclic compounds in organic chemistry.1

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