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The Use of P-Toluenesulfonic Acid for Removal of the N-T-Butoxy-Carbonyl Protecting Group in Solid Phase Peptide Synthesis

✍ Scribed by Brinkman, Herbert R.; Landi, John J.; Paterson, Joseph B.; Stone, Paul J.


Book ID
120981016
Publisher
Taylor and Francis Group
Year
1991
Tongue
English
Weight
210 KB
Volume
21
Category
Article
ISSN
0039-7911

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## Abstract We have found a novel way of protecting the hydroxyl function in hydroxy‐L‐amino acids, making use of the t‐butoxy group, which is readily split by acids, but not by bases. This group is introduced by acid‐catalysed addition of isobutene to N‐acylated hydroxy‐L‐amino acids. The blockin