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A new approach to the synthesis of 14C labelled DL-malic acid

✍ Scribed by T. V. Ramamurthy; K. V. Viswanathan

Publisher
John Wiley and Sons
Year
1983
Tongue
French
Weight
163 KB
Volume
20
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The 2‐carbon units, glycine and glyoxylate are combined by a mild reaction via the copper chelate of glycine. The resulting β‐hydroxy aspartic acid is converted to DL‐malic acid by means of hydroxylamine 0‐sulfonic acid. The overall yields are in the range of 35–50% in submillimolar preparations.

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