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ChemInform Abstract: Enantioselective Synthesis of (-)-Wikstromol Using a New Approach via Malic Acid.

✍ Scribed by Michael Sefkow


Publisher
John Wiley and Sons
Year
2010
Weight
31 KB
Volume
32
Category
Article
ISSN
0931-7597

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## Abstract The 2‐carbon units, glycine and glyoxylate are combined by a mild reaction via the copper chelate of glycine. The resulting β‐hydroxy aspartic acid is converted to DL‐malic acid by means of hydroxylamine 0‐sulfonic acid. The overall yields are in the range of 35–50% in submillimolar pre