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ChemInform Abstract: A New Enantioselective Synthesis of (2S)-Pipecolic Acid.

✍ Scribed by Claude Agami; Catherine Kadouri-Puchot; Jean-Claude Kizirian


Publisher
John Wiley and Sons
Year
2000
Weight
31 KB
Volume
31
Category
Article
ISSN
0931-7597

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The synthesis of two enantiopure pipecolic acid esters (VI) and (XIII) is reported. Key steps are the intramolecular addition of allyl silane on an iminium double bond, generated via reaction of chiral Ξ²-amino alcohols (I) and (VII), with glyoxal (II).