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A practical approach to the synthesis of 14C-labeled amino acid and simple peptide

✍ Scribed by I. Victor Ekhato; Che C. Huang

Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
394 KB
Volume
34
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A convenient method for the synthesis of phenylmethyl N‐methyl (carboxy‐^14^C) glycine hydrochloride (Z) is described. It involves the carboxylation of transmetalated organostannane compound 4 which itself is accessible by established procedure. Success in preparing the labelled amino acid Z enabled us to synthesize target N‐glycyl‐N‐methyl(carboxy‐^14^C) glycine (10) by conventional coupling protocol.

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