A mild and efficient method for the formation of a key intermediate in penem chemistry
β Scribed by Nigel Hussain; David O. Morgan
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 119 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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## Abstract For Abstract see ChemInform Abstract in Full Text.
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The iodination of N-H or N-benzylpyrazoles using elemental iodine in the presence of CAN as the in situ oxidant is a mild and efficient method to prepare 4-iodopyrazoles containing even electron-withdrawing substituents. The reaction is regioselective since the iodine atom preferred pyrazole instead
The Ziegler intermediate 2, previously used in three total syntheses of forskolin (1) has been synthesized efficiently from enone 3. The key transformation of this sequence is the early and stereoselective introduction of the C-6, C-7 oxygen functional groups present in the natural product. The hig
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