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A facile synthesis of the key intermediate for penems, carbapenems, and related β-lactam antibiotics

✍ Scribed by Masahiko Seki; Takeshi Yamanaka; Tsutomu Miyake; Hiroshi Ohmizu


Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
224 KB
Volume
37
Category
Article
ISSN
0040-4039

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Diastereoselective synthesis of a key in
✍ Takaji Matsumoto; Toshiyuki Murayama; Shigeru Mitsuhashi; Takashi Miura 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 236 KB

Asymmetric synthesis of (S)-5 has been accomplished with an excellent enantiomeric excess by hydrogenation of raeemie 5 using ruthenium-BINAP-diamine-KOH system, followed by oxidation. Magnesium enolate of (2S)-2-methoxycyclohexanone [(S)-5] reacts with the 4-aeetoxyazetidinone 4 to give the key int