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A mild and efficient method for the regioselective iodination of pyrazoles

✍ Scribed by Marı́a Isabel Rodrı́guez-Franco; Isabel Dorronsoro; Ana I Hernández-Higueras; Gema Antequera

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
54 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

The iodination of N-H or N-benzylpyrazoles using elemental iodine in the presence of CAN as the in situ oxidant is a mild and efficient method to prepare 4-iodopyrazoles containing even electron-withdrawing substituents. The reaction is regioselective since the iodine atom preferred pyrazole instead of the benzyl group, and the 4-pyrazolic position instead of other possible positions in the heterocycle.

📜 SIMILAR VOLUMES

ChemInform Abstract: A Mild and Efficien
ChemInform Abstract: A Mild and Efficient Method for the Regioselective Iodination of Pyrazoles.
✍ Maria Isabel Rodriguez-Franco; Isabel Dorronsoro; Ana I. Hernandez-Higueras; Gem 📂 Article 📅 2001 🏛 John Wiley and Sons ⚖ 27 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

A mild and efficient method for esterifi
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Iodine, was found to be a practical and useful Lewis acid catalyst for the esterification of carboxylic acids with alcohols. The high catalytic activity of iodine can be used for the transesterification of esters by different alcohols including tertiary alcohols and sterically hindered primary and s